张璐，女，理学博士，研究员，博士生导师。2013年毕业于香港科技大学，获博士学位。2013年至2017年1月在香港科技大学进行博士后研究。研究成果以第一作者身份发表在Nature Communications, Angewandte Chemie International Edition, Accounts of Chemical Research 等杂志期刊上。2017年1月以高层次人才引进到中科院福建物质结构研究所工作, 任研究员。荣获“福建省青年岗位能手”称号。 

　　电子邮件：luzhang@fjirsm.ac.cn 

　　办公地址：纳米楼1009 

　　办公电话：63173256 

　　研究方向： 运用理论计算方法研究复杂生物体系中的重要物理化学过程。结合分子动力学模拟，马尔科夫态动力学网络模型，量子力学计算手段，以及分子力场，探索复杂凝聚态体系内功能相关的分子机制，并设计调控手段，包括各种RNA、DNA聚合酶的转录机理， 光合作用体系内的能量转移和电子转移等。 

　　招生方向：物理化学，凝聚态物理 

　　代表性论文： 

　　1. Hsieh S.-T., Zhang L., Ye D.-W., Huang X.*, Cheng Y.-C.*, “A Theoretical Study on the Dynamics of Light Harvesting in the Dimeric Photosystem II Core Complex: Regulation and Robustness of Energy Transfer Pathways”, Faraday Discussions, 216, 94-115 (2019) 

　　2. Chen X., Song J., Chen Z.-N., Jin T., Long F., Xie H., Zheng Y.,* Zhuang W.,* Zhang L.*, “Rational Designing of 8-Hydroxyquinolin-Imidazolinone-Based Fluorescent Protein Mutants with Dramatically Red: A Computational Study”, J. Comput. Chem., 39, 2307–2315 (2018) 

　　3. Molodtsov, V., Sineva, E., Zhang, L., Huang, X., Cashel, M., Ades, S. E., Murakami, K. S., “Allosteric effector ppGpp potentiates the inhibition of transcript initiation by DksA”, Molecular Cell, 69 (5), 828 (2018) 

　　4. Chevalier, A., Silva, D. A., Rocklin, G. J., Hicks D. R., Vergara R., Murapa P., Bernard S. M., Zhang, L., Lam K. H., Yao G., Bahl C.D., Miyashita S.I., Goreshnik I., Fuller J.T., Koday M.T., Jenkins C. M., Colvin T., Carter L., Bohn A., Bryan C.M., Fernández-Velasco D. A., Stewart L., Dong M., Huang, X., Jin, R., Wilson, I. A., Fuller, D. H., Baker, D., “Massively parallel de novo protein design for targeted therapeutics”, Nature, 550, 74-79, (2017) 

　　5. Feng, Y.^#, Zhang, L.^#, Wu, S., Liu, Z., Gao, X., Zhang, X., Liu, M., Liu, J., Huang, X., Wang, W., “Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis”, Angew. Chem. Int. Ed. 55 (45), 13990–13994 (2016) 

　　6. Zhang, L., Pardo-Avila, F., Unarta, C. I., Cheung, P.-H. P., Wang, G., Wang, D., and Huang, X., “Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network Models”, Acc. Chem. Res. 49 (4), 687–694 (2016) 

　　7. Zhang, L., Silva, D.-A., Pardo-Avila, F., Wang, D., Huang, X., “Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes”, PLoS. Comp. Bio. 11, e1004354 (2015) 

　　8. Zhang, L., Silva, D.-A., Yue, A., Zhang, H., Yan, Y.J., Huang, X., “Dynamic Protein Conformations Preferentially Drive Energy Transfer along Active Chain of the Photosystem-II Reaction Center”, Nature Communications 5, 4170 (2014) 

　　9. Zhang, L., Silva, D.-A., Yan, Y.J., Huang, X., “Force Field Development for Cofactors in the Photosystem II”, J. Comput. Chem. 33 (25), 1969–1980 (2012)